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In 2014, when University of Wisconsin-Madison engineers announced in the journal Nature Communications that they had developed transparent sensors for use in imaging the brain, researchers around the world took notice.Then the requests came flooding in. "So many research groups started asking us for these devices that we couldn't keep up," says Zhenqiang (Jack) Ma, the Lynn H. Matthias Professor and Vilas Distinguished Achievement Professor in electrical and computer engineering at UW-Madison.Ma's group is a world leader in developing revolutionary flexible electronic devices. The see-through, implantable micro-electrode arrays were light years beyond anything ever created.Although he and collaborator Justin Williams, the Vilas Distinguished Achievement Professor in biomedical engineering and neurological surgery at UW-Madison, patented the technology through the Wisconsin Alumni Research Foundation, they saw its potential for advancements in research. "That little step has already resulted in an explosion of research in this field," says Williams. "We didn't want to keep this technology in our lab. We wanted to share it and expand the boundaries of its applications."As a result, in a paper published Thursday (Oct. 13, 2016) in the journal Nature Protocols, the researchers have described in great detail how to fabricate and use transparent graphene neural electrode arrays in applications in electrophysiology, fluorescent microscopy, optical coherence tomography, and optogenetics. "We described how to do these things so we can start working on the next generation," says Ma.Now, not only are the UW-Madison researchers looking at ways to improve and build upon the technology, they also are seeking to expand its applications from neuroscience into areas such as research of stroke, epilepsy, Parkinson's disease, cardiac conditions, and many others. And they hope other researchers do the same."This paper is a gateway for other groups to explore the huge potential from here," says Ma. "Our technology demonstrates one of the key in vivo applications of graphene. We expect more revolutionary research will follow in this interdisciplinary field."Reference:GP1S036PKGS-00GXP1-RRB-3R0232-50  

It takes a very, very clean room to build a detector sensitive enough to see the light from the beginning of the universe.Work is underway at the U.S. Department of Energy's (DOE's) Argonne National Laboratory on a new "clean room." The new lab will be specially suited for building parts for ultra-sensitive detectors—such as those to carry out improved X-ray research, or for the South Pole Telescope to search for light from the early days of the universe."This will be a unique facility, and a wonderful investment for the future of the laboratory," said Supratik Guha, who heads the Center for Nanoscale Materials, a DOE Office of Science User Facility adjacent to where the new space will be located.Clean rooms are a special kind of laboratory that is heavily filtered and cleaned, so that no free-floating particles interfere with delicate work. Take a cube of air one foot on a side: In a normal room in your house or office, this cube contains about one million free-floating particles of dust, dirt and other materials. In the clean room, it's no more than 100.This environment is what you need to build detectors that can detect the tiniest amount of energy striking the surface."Even a few stray specks of dust in the niobium can throw off the design for these detectors," said Marcel Demarteau, who heads the High Energy Physics Division at Argonne and will be a key user of the new lab.One use for such detectors is in the South Pole Telescope in Antarctica, one of several telescopes searching for light waves that have traveled throughout the universe since the moments after the Big Bang. This kind of light is called the Cosmic Microwave Background radiation.Because the light has traveled across space for the 13.8 billion years since the universe began, it has encountered all sorts of obstacles that slightly change its power spectrum—galaxy clusters, patches of dark matter, even our own atmosphere. "We have to correct for these to map the Cosmic Microwave Background signature we're looking for, but these small perturbations themselves hold an enormous amount of very valuable information about the composition of the universe," Demarteau said.  The most sensitive instruments today to find such signals are detectors made from superconductors. Superconductors are extremely sensitive materials that change properties dramatically when their temperature is raised even a tiny bit, and scientists can build components that react to specific frequencies to detect the signature of the Cosmic Microwave Background. The new clean room should allow researchers to build even more sensitive detectors—think of a camera that takes 150-pixel pictures versus one that can take 500,000-pixel images.The same technology will also offer researchers a chance to get better close-ups of the atomic makeup of objects being studied at the Advanced Photon Source, a DOE Office of Science User Facility at Argonne where scientists use X-rays to study everything from car fuel injectors to proteins that play roles in disease.The Advanced Photon Source sends beams of high-energy X-rays at a sample of whatever scientists are studying: a new solar cell material, a sample of volcanic glass from Greenland, a protein involved in photosynthesis. The X-rays hit the sample and scatter off in all directions. Very sensitive detectors pick up that scatter and reveal the chemical and atomic layout of the sample. The better the detector, the more information you can get; so Advanced Photon Source scientists are always looking for new ways to improve those detectors."The type of detector we want to build, nobody makes commercially: so we have to build our own," said Thomas Cecil, an engineer with the Advanced Photon Source. The new clean room will allow them to experiment with new kinds of transition edge sensors, which he said they hope could eventually improve the sensitivity by one or even two orders of magnitude compared to traditional silicon-based detectors.Building such technology is an excruciatingly delicate process, in which they lay down multiple coatings just a few nanometers thick—less than a hundredth of the diameter of a human hair—of superconducting materials and etch patterns into them. Then they repeat the process all over again, for up to 15 layers.The detector itself is so precise that it's operated at temperatures colder than outer space to achieve maximum sensitivity. "It's an excellent opportunity for us to push the boundaries of what's possible," Cecil said.Other potential uses, Demarteau said, include quantum computing as well as homeland security: building detectors that can pick out the particular signature of a specific kind of radiation, to detect if terrorists are carrying a dirty bomb made out of, for example, cesium-137. 

A group of researchers at Osaka University, succeeded in producing nanostructured gas sensor devices for detecting volatile organic compounds (VOC) in breath for the purpose of healthcare in time equivalent to or shorter than one tenth of the time required for manufacturing conventional gas sensors. This group improved conventional complicated production methods, developing a simple production method of just sintering substrates applied with materials. This gas sensor's sensing response was comparable to the top-of-the-line sensors reported all over the world.Research leading detection of low concentrations of gas present in exhaled human breath to health checkups and early detection and treatment of serious diseases is being performed. As gas sensors using nanomaterials can detect various gases even at low concentrations, installing such sensors in electronic healthcare devices is sought after, and research and development are being actively conducted.Semiconductor gas sensors detect gas through reduced electrical resistance due to gas molecules attached to the surface of crystalline semiconductor materials. For this, gas sensors need a specific surface area of nanomaterials. In order to use nanomaterials for conventional gas sensors, a complicated flow was necessary, from nanomaterials synthesis to cleansing, uniform dispersion of solvent, applying on substrates, and sintering. Thus, there is a concern that manufacturing technology of such gas sensors requires significant time and labor, increasing cost.A group of researchers led by Assistant Professor Tohru Sugahara (SUGANUMA Lab.) at The Institute of Scientific and Industrial Research, Osaka University, succeeded in producing nanostructured gas sensor devices for detecting volatile organic compounds (VOC) in breath for the purpose of healthcare in time equivalent to or shorter than one tenth of the time required for manufacturing conventional gas sensors. This group improved conventional complicated production methods, developing a simple production method of just sintering substrates applied with materials. This gas sensor's sensing response was comparable to the top-of-the-line sensors reported all over the world.Since demand in healthcare products is on the rise, there is a lot of activity in research and development of sensors for checking health and disease by examining the gas components of a person's breath. Breathalyzers for finding out who is driving drunk have already been commercialized. Recently, breath sensors for early detection of life-style diseases such as cancer and diabetes have been developed, but most of them are large, bulky and expensive. If gas sensors with high sensitivity are produced thanks to this group's research results, portable breath sensors enabling early detection of diseases will gain popularity.Reference:KGZ10 KGZ10-SPGMS10RVS  

The new generation linear and angular position sensors from ZF pursue new ways in terms of efficiency. Based on a modular system, the sensor is available as an ANG version for angular position measurements or as a LIN-version for linear position measurements. Whereas the ANG-series adds to the existing range of angular position sensors, the linear position sensor opens a new scope for ZF customers. Possible for these sensors are applications such as hydraulic valves, hydraulic controls, electric drives, pneumatic controls, gear selection / shifting position, ride height and level position detection, throttle valve and pedal position, steering wheel position or as a zero-contact encoder alternative. IP68 classification makes these sensors universal also for use in rough environmental conditions. They comply with industrial / automotive EMC/EMI directives and come with a 12 Bit resolution. Due to the compact size the ANG- and LIN-series require less space than other sensors with a similar performance. The mounting Height is only 6.5 mm which is an extremely flat design for linear and angular position sensing. The LIN-series can measure a range of up to 45 mm, while the ANG series provide a programmable measuring range from 0° to 360° degrees. Due to the quality of the components used, both sensors come with an overall accuracy of ±2% full scale and a linearity of the output signal with ±1% full scale. Custom programming is available for: range, slope and PWM output thus allowing an excellent modification to individual requirements. No mechanical interface means no parts to wear out or jam. The LIN- and ANG-series sensors are non-contact linear position sensors with one or two independent outputs. The sensors operate through the use of Hall Effect technology with magnetic fields generated by permanent magnets. They provide a linear change in voltage output (ratiometric to the input voltage) corresponding to a linear displacement of the actuator magnet. The LIN-sensor includes an actuator magnet which specifically paired to the sensor and is required to assure proper operation. Both sensors are RoHS Compliant and suitable for wide air gap applications. Reference: KY45-34THEB1ATA2S22 KY45-AMS22S5A1BHAFL334 KY45-F56101114 KY45-6015-1002-030  

Harvard University researchers have made the first entirely 3D-printed organ-on-a-chip with integrated sensing. Built by a fully automated, digital manufacturing procedure, the 3D-printed heart-on-a-chip can be quickly fabricated in customized form factors allowing researchers to easily collect reliable data for short-term and long-term studies.This new approach to manufacturing may one day allow researchers to rapidly design organs-on-chips, also known as microphysiological systems, that match the properties of a specific disease or even an individual patient's cells.The research is published in Nature Materials."This new programmable approach to building organs-on-chips not only allows us to easily change and customize the design of the system by integrating sensing but also drastically simplifies data acquisition," said Johan Ulrik Lind, first author of the paper and postdoctoral fellow at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS). Lind is also a researcher at the Wyss Institute for Biologically Inspired Engineering at Harvard University."Our microfabrication approach opens new avenues for in vitro tissue engineering, toxicology and drug screening research," said Kit Parker, Tarr Family Professor of Bioengineering and Applied Physics at SEAS, who coauthored the study. Parker is also a Core Faculty Member of the Wyss Institute.Organs-on-chips mimic the structure and function of native tissue and have emerged as a promising alternative to traditional animal testing. Harvard researchers have developed microphysiological systems that mimic the microarchitecture and functions of lungs, hearts, tongues and intestines.However, the fabrication and data collection process for organs-on-chips is expensive and laborious. Currently, these devices are built in clean rooms using a complex, multi-step lithographic process and collecting data requires microscopy or high-speed cameras."Our approach was to address these two challenges simultaneously via digital manufacturing," said Travis Busbee, coauthor of the paper and graduate student in the Lewis Lab. "By developing new printable inks for multi-material 3D printing, we were able to automate the fabrication process while increasing the complexity of the devices."The researchers developed six different inks that integrated soft strain sensors within the micro-architecture of the tissue. In a single, continuous procedure, the team 3D printed those materials into a cardiac microphysiological device—a heart on a chip—with integrated sensors."We are pushing the boundaries of three-dimensional printing by developing and integrating multiple functional materials within printed devices," said Jennifer Lewis, Hansjorg Wyss Professor of Biologically Inspired Engineering, and coauthor of the study. "This study is a powerful demonstration of how our platform can be used to create fully functional, instrumented chips for drug screening and disease modeling."The chip contains multiple wells, each with separate tissues and integrated sensors, allowing researchers to study many engineered cardiac tissues at once. To demonstrate the efficacy of the device, the team performed drug studies and longer-term studies of gradual changes in the contractile stress of engineered cardiac tissues, which can occur over the course of several weeks."Researchers are often left working in the dark when it comes to gradual changes that occur during cardiac tissue development and maturation because there has been a lack of easy, non-invasive ways to measure the tissue functional performance," said Lind. "These integrated sensors allow researchers to continuously collect data while tissues mature and improve their contractility. Similarly, they will enable studies of gradual effects of chronic exposure to toxins.""Translating microphysiological devices into truly valuable platforms for studying human health and disease requires that we address both data acquisition and manufacturing of our devices," said Parker. "This work offers new potential solutions to both of these central challenges."Reference:KY45-59020-010KY45-59135-020KY45-MK21P-1B90C-500W   

For people with celiac disease or gluten intolerances, dining out can be stressful. Even trace amounts of the protein—found in wheat, barley, and rye—in a whole plate of food can cause adverse reactions.Now MIT spinout Nima—co-founded by CEO Shireen Yates MBA '13 and Chief Product Officer Scott Sundvor '12—has developed a portable, highly sensitive gluten sensor that lets diners know if their food is, indeed, safe to eat.According to the National Institutes of Health, celiac disease, an autoimmune disorder that leads to intestinal damage when gluten is eaten, affects around 1 percent of the U.S. population, or roughly 3 million people. According to the National Foundation for Celiac Awareness, millions more may suffer from nonceliac gluten intolerances.Nima's sensor, also called Nima, is a 3-inch-tall triangular device with disposable capsules. Diners put a sample of food—about the size of a pea—or liquid into the capsule, screw on the top, and insert the capsule into the device, which mixes the food into a solution that detects gluten. In two to three minutes, a digital display appears on the sensor, indicating if the food sample does or doesn't contain gluten.Every time someone runs a test, the result is automatically sent to an app Nima has developed. The diner can enter information about where and what they ate, and whether the food contained gluten. Any Nima user can log in to see the results.The aim is to create "a peace of mind at mealtime," Sundvor says. By amassing data on food, he adds, the startup hopes to provide people with better information about what they eat. "Right now, we don't know what's in our food, whether it is allergens, pesticides, or other harmful chemicals," he says. "There's not a good way to get that data. We want to give people the ability to understand their food better and how it affects their health."Sensitive sensorNima can sense gluten at 20 parts per million (ppm) or more, the maximum concentration for "gluten-free" foods as determined by the U.S. Food and Drug Administration.Nima's high sensitivity comes from the immunoassay inside the sensor, developed primarily by MIT chemical engineering alumnus Jingqing Zhang SM '12, PhD '13, who is now the lead scientist at Nima. The immunoassay contains custom antibodies that are highly sensitive to gluten molecules. When gluten is present, the antibody bonds to the gluten molecules, causing a color change in the immunoassay, which is captured by an optical reader. If any gluten is detected, the sensor will display an icon with a "gluten found" message. If the sample has less than 20 ppm of gluten, the sensor will display a smiley face.Nima can detect gluten in foods that are labeled as "gluten-free" but may have picked up microscopic amounts of the protein during the production or cooking process. A steak may have been fried on the same grill as gluten-based foods, for example, or a salad dressing may contain trace amounts of wheat flour. The device can even detect if someone touched a piece of bread that contained gluten, before handling the food in question. "It's the equivalent to finding a breadcrumb in an entire plate of food," Sundvor says.Moreover, Sundvor says, the device seamlessly integrates that chemistry with electronics and mechanics. "We've created this grinding, mixing, and extracting system, and together it works really well," he says.Filling the consumer gapNima was founded in 2013 as GlutenTech, when Yates, then an MIT Sloan School of Management student, dreamt up an idea for a portable gluten sensor. Seeking an engineer to bring the device to life, she met Sundvor, a recent MIT graduate who had studied mechanical engineering and product design.Together, they set up shop at the now-defunct MIT Beehive, a startup incubator on MIT's campus, with aims of filling "a huge consumer gap" in food-allergen testing, Sundvor says. Conventional at-home tests, he says, require equipment such as test tubes, pipettes, a mortar and pestle, and microscale. "You can't bring test tubes to a restaurant," he says.Sundvor began working long hours in an MIT machine shop building a prototype, while Yates brought the idea around to her MIT Sloan classes. Of note was a particular pricing class, where students sketched out pricing and demand models for the product. "The result of that was that I found there's a real opportunity here: There's a need and a willingness to pay," Yates says.In spring 2013, GlutenTech entered the MIT $100K Entrepreneurship Competition with a proof-of-concept model, and they earned the Audience Choice Award in the Accelerate contest. That summer, the team entered the Global Founders Skills Accelerator (GFSA), a 12-week startup program held at the Martin Trust Center for MIT Entrepreneurship.Participating in the $100K forced the team develop a business plan they could pitch to investors, Yates says. "It was a testing period to see, if we position ourselves in a certain way, will it resonate with investors?" she says."The GFSA was incredible," Sundvor adds, "It gave us the opportunity to have a safe space to go full-out on this for three months, have mentors, and have just enough money to squeak by."By the time the GFSA Demo Day rolled around in September, GlutenTech had its first working prototypes—"which were so ugly," Sundvor says, laughing.The 9-inch-long aluminum tubes "looked like lightsaber handles," Sundvor says. Inside the tubes were chemicals used in conventional food tests, and the system took about 10 minutes to detect gluten. When it did, a bright light flashed and a loud alarm went off. "We got many looks at restaurants," Sundvor says. "But they worked and got us our first investors."Three years ago, GlutenTech moved headquarters from Boston to San Francisco, and changed its name to 6SensorLabs. This year, they renamed the startup as Nima. In three years, the startup has gained more than $14 million in capital venture funding.New opportunitiesConsumers are the startup's first market. But as more individuals start using Nima, restaurants will have more data on their food to better serve patrons, Sundvor says. A couple of restaurants in San Francisco, in fact, are working with Nima on validating their gluten-free menu items.Next year, Nima plans to release two new sensors, one for peanuts and one for dairy, which is "surprisingly sneaky," Sundvor says. Bread at a restaurant, for instance, could have been fried in a pan with remnants of butter. "A lot of people are getting sick from dairy allergies, so that will be a big market," Sundvor says.Reference:LM50BIM3/NOPBDS18B20-PAR+T&RAD592BNZ